Senior Scientist, Chemistry (Early Discovery)
Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide foot printing of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first-in-class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against targets that have been considered traditionally undruggable.
We are uniquely structured with opportunities for all scientists to contribute to both established programs as well as ongoing early target selection, screens and validation. We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.
As a scientist in the early discovery group, the successful candidate will contribute to the growth of Vividion’s proprietary drug discovery platform in the context of hit validation and lead compound generation. An exceptional candidate will be comfortable balancing the use of traditional lead identification approaches as well as exploring novel cutting edge covalent chemistry as applied to small-molecule drug discovery.
The preferred candidate will have significant experience in medicinal chemistry and in particular in novel lead finding techniques (HTS triage, virtual screening techniques, scaffold hopping, fragment-based drug discovery). This position will be responsible for identifying novel chemical matter against the functional sites discovered using Vividion’s proprietary chemical proteomics platform.
Education and Experience requirements:
- PhD in synthetic organic chemistry or a chemistry-focused chemical biology program
- 5+ years of post-graduate experience in chemistry, chemical biology or pharmaceutical chemistry
- Clear understanding of medicinal chemistry and an ability to evaluate and prioritize various chemotypes
- Experience managing external CRO chemists
- Strong background in novel lead finding efforts
Required Key Attributes:
- Effective troubleshooting and problem-solving skills
- Excellent oral and written communication skills
- Be an effective team player and strong individual contributor, flexible, and able to handle multiple tasks and deliver high quality results under tight timelines
In addition to a competitive compensation package with long-term incentives and 401k match, Vividion also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, life, and disability insurance.
Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.